- Estradiol Valerate
- Benzyl alcohol
- Benzyl benzoate
Legal Category: prescription only medicine
Pharmaceutical form: clear, colorless to yellow oil solution for injection
Dosage: one injection every 4 weeks
Half-life: 5 days
Estradiol Valerate is a hormone replacement therapy (HRT) used as a substitution for the lack of estrogen production by the ovaries. The production of estrogen happens during menopause or after the removal of the ovaries. The purpose of Estradiol Valerate is to ease the symptoms of menopause caused by estrogen deficiency. Among these symptoms, there are hot flushes, night sweats, sleeplessness, vaginal dryness, headaches, mood swings, lack of concentration, and loss of energy. Besides, Estradiol Valerate is used for osteoporosis, meaning that it helps the prevention of postmenopausal bone loss and reduces the risk of fracture. Oestrogen represents an active form of the female hormone estrogen that stimulates the development of female sexual characteristics, such as breast development. Therefore, Estradiol Valerate is used as transgender hormone therapy for male to female transsexuals. Also, it induces metabolic changes, such as fat distribution to redefine the body shape.
Intramuscular injection is preferred to the detriment of the oral version because it has a long duration, which means that the bioavailability of Estradiol Valerate is complete when injected.
- breast tenderness and breast pain;
- abdominal pain;
- Oedema - fluid retention in the body;
- skin rash and itching;
- changes in liver function (at higher doses);
- risk of dementia (in women older than 65 years).